SEPLINE 10

Composition: Amitriptyline 10mg

Packing: 10×10 (BLISTER)

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💊 Amitriptyline 10 mg Tablet – Comprehensive Medical Explanation

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🔹 What is Amitriptyline?

Amitriptyline is a tricyclic antidepressant (TCA). While it was originally developed to treat depression, today it’s more commonly used at lower doses to treat a variety of conditions including chronic pain, migraine prevention, anxiety, insomnia, and some gastrointestinal disorders like IBS.

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🔹 Brand Names:

• SEPLINE 10

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🔬 How Amitriptyline Works (Mechanism of Action)

Amitriptyline works by:

1. Inhibiting reuptake of two important neurotransmitters in the brain:
   • Serotonin (5-HT)
   • Norepinephrine (Noradrenaline)
2. This increases their levels in the brain, improving:
   • Mood regulation (for depression & anxiety)
   • Pain modulation (used in nerve pain & fibromyalgia)
   • Sleep quality (as it has sedative properties)

Additionally, it has anticholinergic effects (blocks acetylcholine), which contributes to both its therapeutic actions and side effects.

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🩺 Indications (What It’s Used For)

Condition	Typical Dose (Can vary)	Notes
Depression	50–150 mg/day	Higher dose needed
Chronic nerve pain (neuropathy, fibromyalgia)	10–50 mg/day	Low doses effective
Migraine prophylaxis	10–25 mg/day	Taken at night
Irritable Bowel Syndrome (IBS)	10–25 mg/day	Helps pain and sleep
Insomnia (off-label)	10–25 mg before bed	Very effective sedative

At 10 mg, the drug is often prescribed for:

• Initial therapy
• Elderly or sensitive patients
• Off-label use (like sleep aid or migraine prevention)

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⏱️ How to Take It

• Take once daily at bedtime (due to sedative effect).
• Can be taken with or without food.
• Do not split, crush or chew unless instructed.

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⚠️ Precautions and Warnings

✅ Use With Caution If You Have:

• Heart disease (can cause arrhythmias, prolong QT interval)
• Seizure disorders
• Liver dysfunction
• Elderly – more prone to confusion, falls, urinary retention
• Bipolar disorder – can induce mania

🚫 Do NOT Take If:

• You’ve taken MAO inhibitors in the past 14 days.
• You’ve recently had a heart attack.
• You have narrow-angle glaucoma or urinary retention. Products Categories

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🧪 Side Effects – Common & Serious

🟡 Common (Usually Dose-Related):

• Drowsiness or sedation
• Dry mouth
• Constipation
• Blurred vision
• Weight gain
• Dizziness or light-headedness

🔴 Serious (Need Urgent Medical Attention):

• Irregular heartbeat
• Seizures
• Confusion or hallucinations
• Severe allergic reactions
• Suicidal thoughts (especially in younger patients)

Most side effects lessen over time, but they must be monitored closely during the first few weeks of treatment.

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🔄 What to Expect After Starting

Timeline	What Happens
1–7 days	Sedation, better sleep
1–2 weeks	Reduced anxiety or pain
2–4 weeks	Improvement in mood/depression
Ongoing	Continued improvement in symptoms; doctor may adjust dose

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🚫 Do Not Stop Suddenly

Stopping amitriptyline abruptly can cause withdrawal symptoms such as:

• Headache
• Irritability
• Nausea
• Sleep disturbances
• Flu-like symptoms

Always taper the dose gradually under medical supervision.

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🔄 Interactions to Watch Out For

• Alcohol: Increases drowsiness and risk of overdose.
• Other antidepressants (SSRIs, SNRIs): Risk of serotonin syndrome.
• Anticholinergics (e.g., antihistamines, some antipsychotics): May increase side effects.
• Blood pressure meds: Amitriptyline may alter effectiveness.

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🧴 Storage Instructions

• Store at room temperature (20–25°C).
• Keep away from light, heat, and moisture.
• Keep out of reach of children.

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✅ Summary – Amitriptyline 10 mg

Feature	Detail
Best For	Pain, sleep, anxiety, migraine
Dose	10 mg at bedtime
Effect Starts	Within 1–2 weeks
Common Side Effects	Drowsiness, dry mouth, constipation
Key Warning	Cardiac issues, don’t mix with MAOIs
Tapering	Required if discontinuing

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🧑‍⚕️ Doctor’s Advice:

• Amitriptyline is very effective in low doses for many non-depressive conditions.
• Monitor for side effects, especially in older adults and those with heart conditions.
• Stay in close contact with your healthcare provider during the first few weeks.
• This medication is not addictive, but must be tapered off if discontinued.

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